San Antonio is a sub-region of the Aconcagua Valley and is divided into four sectors: Leyda, Lo Abarca, Rosario, and Malvilla.

Vineyards taunt the cold Pacific climate as they creep ever closer to its coast in this relatively new wine region. Vines bedeck the rolling hillsides as close as 2.5 miles (4 km) from the sea and test the mettle of strong-willed growers and pioneering winemakers. The work pays off with crisp, lean, mineral-fresh whites and spicy reds that increasingly turn heads.