The Santa Cruz Mountains AVA is a Viticultural Area that is based around the Santa Cruz Mountains in California. The appellation enjoys a large diveristy of micro-climates, affected by the mountain topography, the Pacific Ocean, and the nearby San Francisco Bay.

The  wine appellation encompasses 1,500 acres of vineyards, dominated by mainly Pinot noir, Cabernet Sauvignon, Chardonnay, with more smaller blocks of Cabernet Franc, Carignane, Dolcetto, Grenache, Malbec, Malvasia, Merlot, Mondeuse, Mourvedre, Nebbiolo, Petit Verdot, Petite Sirah, Sangiovese, Sauvignon Blanc, Syrah, Viognier, Zinfandel.

Notable wineries in the appellation include: Bonny Doon Vineyard,  Ridge Vineyards , Neely